BDBM321058 MLN4924::N-[(1S)-1-indanyl]-7-[(1R)-3alpha-hydroxy-4∝-(sulfamoyloxymethyl)cyclopentyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine::US10174040, Comparative Example

SMILES NS(=O)(=O)OC[C@@H]1C[C@H](CC1O)n1ccc2c(N[C@H]3CCc4ccccc34)ncnc12

InChI Key InChIKey=MPUQHZXIXSTTDU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 321058   

TargetCarbonic anhydrase 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321058(US10174040, Comparative Example | N-[(1S)-1-indany...)
Affinity DataIC50: 12nMAssay Description:The carbonic anhydrase II enzyme activity inhibition was measured by measuring the esterase activity in which carbonic anhydrase II degrades 4-nitrop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetNEDD8-conjugating enzyme UBE2F(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321058(US10174040, Comparative Example | N-[(1S)-1-indany...)
Affinity DataIC50: 33nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent