BDBM321067 6-(1,5-dimethyl-1H- pyrazol-3-yl)-4-(6- (piperazin-1-yl)pyridin-3- yl)pyrazolo[1,5-a]pyridine- 3-carbonitrile dihydrochloride::US10174028, Example 627

SMILES Cc1cc(cn1C)-c1cc(-c2ccc(nc2)N2CCNCC2)c2c(cnn2c1)C#N

InChI Key InChIKey=IGWIAAMGKWCSRA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 321067   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM321067(US10174028, Example 627 | 6-(1,5-dimethyl-1H- pyra...)
Affinity DataIC50: 66.6nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandPNGBDBM321067(US10174028, Example 627 | 6-(1,5-dimethyl-1H- pyra...)
Affinity DataIC50: 513nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent