BDBM322660 US10183944, Example 29::US10647720, Ex. # 29::methyl 4-(4-(4-morpholinophenylamino)- 5-oxo-5,6-dihydropyrimido[4,5- d]pyridazin-2-yl)benzoate

SMILES COC(=O)c1ccc(cc1)-c1nc(Nc2ccc(cc2)N2CCOCC2)c2c(cn[nH]c2=O)n1

InChI Key InChIKey=XDZCRXUBYJHSDR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 322660   

TargetTyrosine-protein kinase SYK(Human)
Asan Biosciences

US Patent
LigandPNGBDBM322660(methyl 4-(4-(4-morpholinophenylamino)- 5-oxo-5,6-d...)
Affinity DataIC50: 100nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Asan Biosciences

US Patent
LigandPNGBDBM322660(methyl 4-(4-(4-morpholinophenylamino)- 5-oxo-5,6-d...)
Affinity DataIC50: 100nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent