BDBM326124 US10273223, Compound D-22::US9637472, Compound D-22

SMILES Cc1cc(CN2CCC[C@@H]2C(N)=O)c(CNC(=O)c2cc(Br)cc3n(ncc23)C2CCCC2)c(=O)[nH]1

InChI Key InChIKey=HZEXJRFSCNZXBG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 326124   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme

US Patent
LigandPNGBDBM326124(US9637472, Compound D-22 | US10273223, Compound D-...)
Affinity DataIC50: 2.00E+3nMAssay Description:eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme

US Patent
LigandPNGBDBM326124(US9637472, Compound D-22 | US10273223, Compound D-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent