BDBM326681 (3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 398

SMILES Fc1cnc(nc1)-c1c(F)cccc1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F

InChI Key InChIKey=UDXPHTSAAGLKFL-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 326681   

TargetOrexin/Hypocretin receptor type 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM326681((3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)((1S,2R...)
Affinity DataKi:  61nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM326681((3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)((1S,2R...)
Affinity DataKi:  81nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM326681((3-fluoro-2-(5-fluoropyrimidin-2-yl)phenyl)((1S,2R...)
Affinity DataKi:  2.10E+3nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent