BDBM331653 Preparation of ((2-(3-fluoro-4-(2-oxo-2-((5-(1-(trifluoromethyl)cyclopropyl)isoxazol-3-yl)amino)ethyl)phenyl)quinoxaline-6,7-diyl)bis(oxy))bis(ethane-2,1-diyl) diacetate::US9725465, Example 74

SMILES CC(=O)OCCOc1cc2ncc(nc2cc1OCCOC(C)=O)-c1ccc(CC(=O)Nc2cc(on2)C2(CC2)C(F)(F)F)c(F)c1

InChI Key InChIKey=ZYTXDAJAAUPBNX-UHFFFAOYSA-N

Data  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 331653   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM331653(US9725465, Example 74 | Preparation of ((2-(3-fluo...)
Affinity DataKd: <5nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM331653(US9725465, Example 74 | Preparation of ((2-(3-fluo...)
Affinity DataKd:  12.5nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent