BDBM333617 US9730937, Example 166::ethyl 2-(3- tert-butyl-5- {3-[3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl] ureido}-1H- pyrazol-1- yl)acetate

SMILES CCOC(=O)Cn1nc(cc1NC(=O)Nc1cccc(Oc2ncnc3cc(OC)c(OC)cc23)c1)C(C)(C)C

InChI Key InChIKey=REZIYFNDWNZROB-UHFFFAOYSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 333617   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Ambit Biosciences

US Patent
LigandPNGBDBM333617(ethyl 2-(3- tert-butyl-5- {3-[3-(6,7- dimethoxy- q...)
Affinity DataKd:  375nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM333617(ethyl 2-(3- tert-butyl-5- {3-[3-(6,7- dimethoxy- q...)
Affinity DataKd: >1.00E+3nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM333617(ethyl 2-(3- tert-butyl-5- {3-[3-(6,7- dimethoxy- q...)
Affinity DataKd: >1.00E+3nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent