BDBM333848 1-(3-tert-butyl- 1-(4- methoxy- phenyl)- 1H-pyrazol-5- yl)- 3-(3-(6,7- dimethoxy- quinazolin- 4-yloxy) phenyl) urea::US9730937, Example 398

SMILES COc1ccc(cn1)-n1nc(cc1NC(=O)Nc1cccc(Oc2ncnc3cc(OC)c(OC)cc23)c1)C(C)(C)C

InChI Key InChIKey=XQTZSDVQGIEMGR-UHFFFAOYSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 333848   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Ambit Biosciences

US Patent
LigandPNGBDBM333848(1-(3-tert-butyl- 1-(4- methoxy- phenyl)- 1H-pyrazo...)
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM333848(1-(3-tert-butyl- 1-(4- methoxy- phenyl)- 1H-pyrazo...)
Affinity DataKd:  750nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM333848(1-(3-tert-butyl- 1-(4- methoxy- phenyl)- 1H-pyrazo...)
Affinity DataKd:  750nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent