BDBM33489 4-Methyl-2-phenyl-6-(4-phenyl-piperazin-1-yl)-pyrimidine::4-methyl-2-phenyl-6-(4-phenyl-1-piperazinyl)pyrimidine::4-methyl-2-phenyl-6-(4-phenylpiperazin-1-yl)pyrimidine::4-methyl-2-phenyl-6-(4-phenylpiperazino)pyrimidine::MLS000035234::SMR000000736::cid_646531

SMILES Cc1cc(nc(n1)-c1ccccc1)N1CCN(CC1)c1ccccc1

InChI Key InChIKey=OGEGHNXZKVBMSM-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 33489   

TargetProthrombin(Homo sapiens (Human))
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM33489(4-Methyl-2-phenyl-6-(4-phenyl-piperazin-1-yl)-pyri...)
Affinity DataIC50: >5.00E+4nMpH: 7.5 T: 2°CAssay Description:HTS was performed using 217,350 compounds of the MLSCN library individually plated into 10ul 1536 compound plates at a concentration of 2.5 mM each, ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetBcl-2-like protein 11(Homo sapiens (Human))
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM33489(4-Methyl-2-phenyl-6-(4-phenyl-piperazin-1-yl)-pyri...)
Affinity DataEC50: >3.50E+5nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetKallikrein-5(Homo sapiens (Human))
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM33489(4-Methyl-2-phenyl-6-(4-phenyl-piperazin-1-yl)-pyri...)
Affinity DataIC50:  5.00E+4nMAssay Description:Molecular Library Screening Center Network (MLSCN) Penn Center for Molecular Discovery (PCMD) Assay Provider: Scott L. Diamond, University of Pennsy...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay