BDBM336713 US9745283, Example 142

SMILES CCn1cc(C(=O)Nc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)c(=O)n(-c2ccc(F)cc2)c1=O

InChI Key InChIKey=LQCSHRGTVAWATB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 336713   

TargetTyrosine-protein kinase receptor UFO(Human)
Ignyta

US Patent
LigandPNGBDBM336713(US9745283, Example 142)
Affinity DataIC50: 10nMAssay Description:The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
Ignyta

US Patent
LigandPNGBDBM336713(US9745283, Example 142)
Affinity DataIC50: 55nMAssay Description:The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent