BDBM340569 1-(3-((4-(1H-pyrazol-4-yl)phenyl)amino)-1-(cyclopropylmethyl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)ethanone::US9763922, Example 98

SMILES CC(=O)N1CCc2c(c(Nc3ccc(-c4cn[nH]c4)cc3)nn2CC2CC2)C1

InChI Key InChIKey=OYWJHWUQFLUJAI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 340569   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 340569BDBM340569(US9763922, Example 98 | 1-(3-((4-(1H-pyrazol-4-yl)...)
Affinity DataIC50: 20nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 340569BDBM340569(US9763922, Example 98 | 1-(3-((4-(1H-pyrazol-4-yl)...)
Affinity DataIC50: 4.42E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2019
Entry Details
US Patent