BDBM340749 1-[3-[3-fluoro-4-(1-methylpyrazol-4-yl)anilino]-1-(2-hydroxy-1-methyl-ethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone::US9763922, Example 275

SMILES CC(CO)n1nc(Nc2ccc(-c3cnn(C)c3)c(F)c2)c2CN(CCc12)C(C)=O

InChI Key InChIKey=HRXQUJZMTSXBOH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 340749   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM340749(US9763922, Example 275 | 1-[3-[3-fluoro-4-(1-methy...)
Affinity DataIC50: 20nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
Genentech

US Patent
LigandPNGBDBM340749(US9763922, Example 275 | 1-[3-[3-fluoro-4-(1-methy...)
Affinity DataIC50: 4.89E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2019
Entry Details
Go to US Patent