BDBM3428 1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea::6-arylpyrido[2,3-d]pyrimidine deriv. 1::CHEMBL57366::PD089828

SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(Cl)cccc1Cl

InChI Key InChIKey=RRWSNCZYJCOEFX-UHFFFAOYSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 3428   

TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pfizer

LigandPNGBDBM3428(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Affinity DataIC50:  1.20E+3nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3428(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibitory activity against platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Pfizer

LigandPNGBDBM3428(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Affinity DataIC50:  220nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pfizer

LigandPNGBDBM3428(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Affinity DataIC50:  1.25E+3nMpH: 7.4 T: 2°CAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In DepthDetails Article
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3428(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Affinity DataIC50:  140nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In DepthDetails Article
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Pfizer

LigandPNGBDBM3428(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Affinity DataIC50:  220nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...More data for this Ligand-Target Pair
In DepthDetails Article
TargetInsulin receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM3428(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of insulin receptor (InsR) tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Pfizer

LigandPNGBDBM3428(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Affinity DataIC50:  220nMAssay Description:Inhibition of C-src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM3428(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Affinity DataIC50:  450nMAssay Description:Inhibition of Epidermal growth factor receptor (EGFr) tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM3428(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Affinity DataIC50:  560nMAssay Description:Inhibition of FGFR4 (unknown origin) after 90 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM3428(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Affinity DataIC50:  290nMAssay Description:Inhibition of FGFR3 (unknown origin) after 90 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Health Science Center Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM3428(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Affinity DataIC50:  130nMAssay Description:Inhibition of FGFR2 (unknown origin) after 90 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3428(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Affinity DataIC50:  110nMAssay Description:Inhibition of FGFR1 (unknown origin) after 90 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM3428(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Affinity DataIC50:  450nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3428(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibitory activity against platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3428(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails Article
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3428(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibitory activity against platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInsulin receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM3428(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Insulin receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3428(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Affinity DataIC50:  140nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed