BDBM345019 2-{3-[1-(2-fluorophenyl)-::2-{3-[1-(2-fluorophenyl)-1H-indazol-4-yl]-2-oxoimidazolidin-1-yl}-N-(oxetan-3-yl)acetamide::US9783527, Example 321

SMILES Fc1ccccc1-n1ncc2c(cccc12)N1CCN(CC(=O)NC2COC2)C1=O

InChI Key InChIKey=SNUWEOKYYJFNJG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 345019   

LigandPNGBDBM345019(2-{3-[1-(2-fluorophenyl)-1H-indazol-4-yl]-2-oxoimi...)
Affinity DataIC50: 5.67E+3nMAssay Description:Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.8 (Essen, Ann Arbor, Mich.) were quickly thawed and pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Abbvie

US Patent
LigandPNGBDBM345019(2-{3-[1-(2-fluorophenyl)-1H-indazol-4-yl]-2-oxoimi...)
Affinity DataIC50: 5.79E+3nMAssay Description:Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.7 were quickly thawed and plated at 25,000 cells/well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
Go to US Patent