BDBM345412 5-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroimidazol-1-yl]sulfonyl]-1-methyl-benzimidazole::US10202354, Example 77

SMILES Cn1cnc2cc(ccc12)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1

InChI Key InChIKey=AWSCWSFNZVGROH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 345412   

TargetLysine-specific demethylase 2B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 345412BDBM345412(5-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroimid...)
Affinity DataIC50: 0.195nMAssay Description:Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
US Patent