BDBM345454 1-ethyl-4-[1-(1-ethyl-5-methyl-pyrazol-4-yl)sulfonyl-4,5-dihydroimidazol-2-yl]piperazine::US10202354, Example 119

SMILES CCN1CCN(CC1)C1=NCCN1S(=O)(=O)c1cnn(CC)c1C

InChI Key InChIKey=MTENDOYBSMFGEI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 345454   

TargetLysine-specific demethylase 2B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 345454BDBM345454(US10202354, Example 119 | 1-ethyl-4-[1-(1-ethyl-5-...)
Affinity DataIC50: 11.4nMAssay Description:Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
US Patent