BDBM347716 Ethyl 2-[(Z)-2-(4-cyanophenoxy)-3- (dimethylamino)prop-2-enoyl]benzoate::US9790217, 39::US9790217, 40

SMILES CCOC(=O)c1ccccc1C(=O)C(\Oc1ccc(cc1)C#N)=C\N(C)C

InChI Key InChIKey=MVRHRHGUPLIRAA-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 347716   

TargetCytochrome P450 11B2, mitochondrial(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM347716(US9790217, 40 | Ethyl 2-[(Z)-2-(4-cyanophenoxy)-3-...)
Affinity DataEC50:  0.0340nMAssay Description:G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM347716(US9790217, 40 | Ethyl 2-[(Z)-2-(4-cyanophenoxy)-3-...)
Affinity DataEC50:  1.16nMAssay Description:G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM347716(US9790217, 40 | Ethyl 2-[(Z)-2-(4-cyanophenoxy)-3-...)
Affinity DataEC50:  1.5nMAssay Description:G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM347716(US9790217, 40 | Ethyl 2-[(Z)-2-(4-cyanophenoxy)-3-...)
Affinity DataEC50: >30nMAssay Description:G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent