BDBM349077 Cyclopropanecarboxylic acid {5-[4-(1-hydroxy-pyridin-3- ylmethoxy)-phenyl]- [1,2,4]triazolo[1,5-a]pyridin-2- yl}-amide::US10206907, Compound 196

SMILES [O-][n+]1cccc(COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c1

InChI Key InChIKey=FCSDSHSQMYROSC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349077   

TargetTyrosine-protein kinase JAK1 [850-1154](Human)
Galapagos

US Patent
LigandPNGBDBM349077(Cyclopropanecarboxylic acid {5-[4-(1-hydroxy-pyrid...)
Affinity DataIC50: 100nMAssay Description:Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Galapagos

US Patent
LigandPNGBDBM349077(Cyclopropanecarboxylic acid {5-[4-(1-hydroxy-pyrid...)
Affinity DataIC50: 300nMAssay Description:Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent