BDBM349231 (R)-3-(3-cyclopropyl-5-((R)-4-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-6-yl)-1-indazol-1-yl)butanenitrile & (S)-3-(3-cyclopropyl-5-((R)-4-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-6-yl)-1H-indazol-1-yl)butanenitrile::US10206931, Example 38

SMILES C[C@H](CC#N)Nc1ccc(cc1C(=N)C1CC1)-c1cccc2NC(=O)C[C@@H](C)Nc12

InChI Key InChIKey=IISJJIPXEVQWBW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349231   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349231BDBM349231((R)-3-(3-cyclopropyl-5-((R)-4-methyl-2-oxo-2,3,4,5...)
Affinity DataIC50: 119nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349231BDBM349231((R)-3-(3-cyclopropyl-5-((R)-4-methyl-2-oxo-2,3,4,5...)
Affinity DataIC50: 2.74E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent