BDBM349242 4-[(Z)-2-fluoro-1-methyl-2-[(4R)-4-methyl-2-oxo-1,3,4,5-tetrahydro-1,5-benzodiazepin-6-yl]vinyl]benzonitrile::US10206931, Example 49

SMILES C[C@@H]1CC(=O)Nc2cccc(\C(F)=C(/C)c3ccc(cc3)C#N)c2N1

InChI Key InChIKey=RYLYUTXKTYSUMQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349242   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349242BDBM349242(4-[(Z)-2-fluoro-1-methyl-2-[(4R)-4-methyl-2-oxo-1,...)
Affinity DataIC50: 736nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349242BDBM349242(4-[(Z)-2-fluoro-1-methyl-2-[(4R)-4-methyl-2-oxo-1,...)
Affinity DataIC50: 1.97E+4nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent