BDBM349270 (4R) N-(5-isopropoxy-3-pyridyl)-4-methyl-2-oxo-1,3,4,5-tetrahydro-1,5-benzodiazepine-6-carboxamide::US10206931, Example 77

SMILES CC(C)Oc1cncc(NC(=O)c2cccc3NC(=O)C[C@@H](C)Nc23)c1

InChI Key InChIKey=WQLIBICVEMGJPS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349270   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349270BDBM349270((4R) N-(5-isopropoxy-3-pyridyl)-4-methyl-2-oxo-1,3...)
Affinity DataIC50: 157nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349270BDBM349270((4R) N-(5-isopropoxy-3-pyridyl)-4-methyl-2-oxo-1,3...)
Affinity DataIC50: 9.30E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent