BDBM349297 (2R)-2-methyl-9-(5-methyl-2-furyl)-3,5-dihydro-2H-1,5-benzoxazepin-4-one::US10206931, Example 104

SMILES C[C@@H]1CC(=O)Nc2cccc(-c3ccc(C)o3)c2O1

InChI Key InChIKey=HNKBSNWHDADQCV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349297   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349297BDBM349297((2R)-2-methyl-9-(5-methyl-2-furyl)-3,5-dihydro-2H-...)
Affinity DataIC50: 840nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349297BDBM349297((2R)-2-methyl-9-(5-methyl-2-furyl)-3,5-dihydro-2H-...)
Affinity DataIC50: 1.37E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent