BDBM349364 (4R)-6-(1-tert-butylpyrazol-4-::US10206931, Example 172
SMILES C[C@@H]1CC(=O)Nc2cccc(-c3cnn(c3)C(C)(C)C)c2N1
InChI Key InChIKey=HPSNXSAYALRMQW-LLVKDONJSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 349364
Affinity DataIC50: 456nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.02E+4nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.10E+3nMAssay Description:Inhibition of NanoLuc tagged CBP bromodomain (unknown origin) expressed in HEK293 cells harboring Halo-tagged histone H3.3 by NanoBRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 470nMAssay Description:Inhibition of His-FLAG-tagged CBP ( 1082 to 1197 residues) (unknown origin) using H4-tetraAc-biotin as substrate incubated for 20 mins by AlphaLISA a...More data for this Ligand-Target Pair
TargetCREB-binding protein/Histone acetyltransferase p300(Homo sapiens (Human))
Jilin University
Curated by ChEMBL
Jilin University
Curated by ChEMBL
Affinity DataIC50: 470nMAssay Description:Inhibition of human His-FLAG tagged CBP/EP300 (1082 to 1197 residues) using H4-TetraAc-biotin peptide as substrate after 90 mins by AlphaLISA methodMore data for this Ligand-Target Pair