BDBM349386 1-methyl-3-[(4R)-4-methyl-::US10206931, Example 194

SMILES C[C@@H]1CC(=O)Nc2cccc(-c3cn(C)c4cc(ccc34)C#N)c2N1

InChI Key InChIKey=XSYRHUHBMOUVDW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349386   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349386BDBM349386(1-methyl-3-[(4R)-4-methyl- | US10206931, Example 1...)
Affinity DataIC50: 226nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 349386BDBM349386(1-methyl-3-[(4R)-4-methyl- | US10206931, Example 1...)
Affinity DataIC50: 6.89E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent