BDBM350853 UNC2125A::US10004755, Compound UNC2125A::US9795606, B12

SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(F)c(F)c1

InChI Key InChIKey=IMQXMHYXTAYQDO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 350853   

TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM350853(US9795606, B12 | UNC2125A | US10004755, Compound U...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM350853(US9795606, B12 | UNC2125A | US10004755, Compound U...)
Affinity DataIC50: 44nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM350853(US9795606, B12 | UNC2125A | US10004755, Compound U...)
Affinity DataIC50: 203nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Mer(Human)
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM350853(US9795606, B12 | UNC2125A | US10004755, Compound U...)
Affinity DataIC50: 250nMAssay Description:The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent