BDBM352496 US10745364, Example 6::US9809561, 6

SMILES CCn1cc(c(Cl)n1)S(=O)(=O)N1C[C@H](Oc2ccc(NC(=O)OC(C)(C)C(F)(F)F)cc12)C(=O)C(F)(F)F

InChI Key InChIKey=BHCJBWDRSDKDKZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 352496   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352496(US9809561, 6 | US10745364, Example 6)
Affinity DataIC50: 11.8nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352496(US9809561, 6 | US10745364, Example 6)
Affinity DataIC50: 11.8nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
US Patent