BDBM352499 US10745364, Example 9::US9809561, 9
SMILES CC(C)(OC(=O)Nc1ccc2O[C@@H](CNC(=O)NC3CCOCC3)CN(c2c1)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F
InChI Key InChIKey=NWQAVNQSLMJINX-IBGZPJMESA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 352499
Affinity DataIC50: 4.23nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
Affinity DataIC50: 4.23nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Affinity DataIC50: 4.23nMAssay Description:HIS-tagged RORγ-LBD protein was recombinantly expressed in Escherichia coli. The RORγ-LBD protein was purified by Ni2+-affinity resin. Puri...More data for this Ligand-Target Pair