BDBM352513 (S)-1,1,1-trifluoro-2-methylpropan-2-yl (4-((4-fluorophenyl)sulfonyl)-2- ((morpholine-4-sulfonamido)methyl)- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6- yl)carbamate::US10745364, Example 13A::US9809561, 13A

SMILES CC(C)(OC(=O)Nc1ccc2O[C@@H](CNS(=O)(=O)N3CCOCC3)CN(c2c1)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F

InChI Key InChIKey=UQCBJOBYZKGFGQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 352513   

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM352513((S)-1,1,1-trifluoro-2-methylpropan-2-yl (4-((4-flu...)
Affinity DataIC50: 7.25nMAssay Description:HIS-tagged RORγ-LBD protein was recombinantly expressed in Escherichia coli. The RORγ-LBD protein was purified by Ni2+-affinity resin. Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM352513((S)-1,1,1-trifluoro-2-methylpropan-2-yl (4-((4-flu...)
Affinity DataIC50: 7.25nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM352513((S)-1,1,1-trifluoro-2-methylpropan-2-yl (4-((4-flu...)
Affinity DataIC50: 7.25nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
US Patent