BDBM352807 US10745364, Example 79A::US9809561, 79A::tert-butyl (7-(hydroxymethyl)-5-(m- tolylsulfonyl)-5,6,7,8-tetrahydro-1,5- naphthyridin-3-yl)carbamate

SMILES Cc1cccc(c1)S(=O)(=O)N1CC(CO)Cc2ncc(NC(=O)OC(C)(C)C)cc12

InChI Key InChIKey=ZAPUMBTZGCGDMX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 352807   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352807(US9809561, 79A | tert-butyl (7-(hydroxymethyl)-5-(...)
Affinity DataIC50: 63.5nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352807(US9809561, 79A | tert-butyl (7-(hydroxymethyl)-5-(...)
Affinity DataIC50: 63.5nMAssay Description:HIS-tagged RORγ-LBD protein was recombinantly expressed in Escherichia coli. The RORγ-LBD protein was purified by Ni2+-affinity resin. Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352807(US9809561, 79A | tert-butyl (7-(hydroxymethyl)-5-(...)
Affinity DataIC50: 63.5nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
US Patent