BDBM352808 US10745364, Example 79B::US9809561, 79B::tert-butyl (5-((3,4-difluorophenyl)sulfonyl)-7- (hydroxymethyl)-5,6,7,8-tetrahydro-1,5- naphthyridin-3-yl)carbamate
SMILES CC(C)(C)OC(=O)Nc1cnc2CC(CO)CN(c2c1)S(=O)(=O)c1ccc(F)c(F)c1
InChI Key InChIKey=SQVLYEPZMKXNHE-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 352808
Affinity DataIC50: 130nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:HIS-tagged RORγ-LBD protein was recombinantly expressed in Escherichia coli. The RORγ-LBD protein was purified by Ni2+-affinity resin. Puri...More data for this Ligand-Target Pair