BDBM352809 (R or S)-neopentyl (5-((4- fluorophenyl)sulfonyl)-7-(hydroxymethyl)- 5,6,7,8-tetrahydro-1,5-naphthyridin-3- yl)carbamate::US10745364, Example 79C::US9809561, 79C

SMILES CC(C)(C)COC(=O)Nc1cnc2C[C@@H](CO)CN(c2c1)S(=O)(=O)c1ccc(F)cc1

InChI Key InChIKey=ZZIMAUFKJSEXAI-CQSZACIVSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 352809   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352809((R or S)-neopentyl (5-((4- fluorophenyl)sulfonyl)-...)
Affinity DataIC50:  603nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352809((R or S)-neopentyl (5-((4- fluorophenyl)sulfonyl)-...)
Affinity DataIC50:  603nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352809((R or S)-neopentyl (5-((4- fluorophenyl)sulfonyl)-...)
Affinity DataIC50:  603nMAssay Description:HIS-tagged RORγ-LBD protein was recombinantly expressed in Escherichia coli. The RORγ-LBD protein was purified by Ni2+-affinity resin. Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent