BDBM35327 pyridylpurine aminoisoquinoline, 1

SMILES Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1Nc1ncccc1-c1ncnc2nc[nH]c12

InChI Key InChIKey=KKVYYGGCHJGEFJ-UHFFFAOYSA-N

Data  2 KI  6 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 35327   

TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM35327(pyridylpurine aminoisoquinoline, 1)
Affinity DataKi:  0.300nMAssay Description:Inhibition of C-RafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM35327(pyridylpurine aminoisoquinoline, 1)
Affinity DataKi:  1nMAssay Description:Inhibition of B-RafMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM35327(pyridylpurine aminoisoquinoline, 1)
Affinity DataIC50:  1.00E+3nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM35327(pyridylpurine aminoisoquinoline, 1)
Affinity DataIC50:  120nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM35327(pyridylpurine aminoisoquinoline, 1)
Affinity DataIC50:  2nMAssay Description:Inhibition of b-Raf in human A375 cells assessed phosphorylation of ERKMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

LigandPNGBDBM35327(pyridylpurine aminoisoquinoline, 1)
Affinity DataIC50: >1.60E+3nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Amgen

LigandPNGBDBM35327(pyridylpurine aminoisoquinoline, 1)
Affinity DataIC50:  1.60nM EC50:  1.80nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

LigandPNGBDBM35327(pyridylpurine aminoisoquinoline, 1)
Affinity DataIC50:  83nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed