BDBM355178 2-methyl-6-oxo-N-{1-[4- (trifluoromethyl)phenyl]cyclobutyl}- 1,6-dihydropyrimidine-4-carboxamide::US9815796, Example 269

SMILES Cc1nc(cc(=O)[nH]1)C(=O)NC1(CCC1)c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=NVNFAHGLGFPVGM-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 355178   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355178(US9815796, Example 269 | 2-methyl-6-oxo-N-{1-[4- (...)
Affinity DataKi:  96nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355178(US9815796, Example 269 | 2-methyl-6-oxo-N-{1-[4- (...)
Affinity DataKi:  118nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355178(US9815796, Example 269 | 2-methyl-6-oxo-N-{1-[4- (...)
Affinity DataKi:  158nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent