BDBM355207 2-cyclopropyl-N-{(1R)-1-[4-(1- methylethyl)phenyl]ethyl}-6-oxo-1,6- dihydropyrimidine-4-carboxamide::US9815796, Example 298

SMILES CC(C)c1ccc(cc1)[C@@H](C)NC(=O)c1cc(=O)[nH]c(n1)C1CC1

InChI Key InChIKey=KCNSPSBCPHTPMW-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 355207   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355207(US9815796, Example 298 | 2-cyclopropyl-N-{(1R)-1-[...)
Affinity DataKi:  13nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355207(US9815796, Example 298 | 2-cyclopropyl-N-{(1R)-1-[...)
Affinity DataKi:  18nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
Go to US Patent