BDBM355268 US9815796, Example 359::methyl 4-[(1R)-1-{[(6-oxo-2-phenyl- 1,6-dihydropyrimidin-4- yl)carbonyl]amino}ethyl]benzoate

SMILES COC(=O)c1ccc(cc1)[C@@H](C)NC(=O)c1cc(=O)[nH]c(n1)-c1ccccc1

InChI Key InChIKey=FAKNPPSYIJHERG-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 355268   

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355268(US9815796, Example 359 | methyl 4-[(1R)-1-{[(6-oxo...)
Affinity DataKi:  62nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355268(US9815796, Example 359 | methyl 4-[(1R)-1-{[(6-oxo...)
Affinity DataKi:  129nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
Go to US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355268(US9815796, Example 359 | methyl 4-[(1R)-1-{[(6-oxo...)
Affinity DataKi:  173nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
Go to US Patent