BDBM355307 N-[(1R)-1-{3-fluoro-4- [(trifluoromethyl)sulfanyl]phenyl}eth- yl]-6-oxo-2-phenyl-1,6- dihydropyrimidine-4-carboxamide::US9815796, Example 398

SMILES C[C@@H](NC(=O)c1cc(=O)[nH]c(n1)-c1ccccc1)c1ccc(SC(F)(F)F)c(F)c1

InChI Key InChIKey=KEQDHQAJGKODSK-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 355307   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355307(US9815796, Example 398 | N-[(1R)-1-{3-fluoro-4- [(...)
Affinity DataKi:  2.30nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355307(US9815796, Example 398 | N-[(1R)-1-{3-fluoro-4- [(...)
Affinity DataKi:  2.90nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
Go to US Patent