BDBM355391 2-(4-methoxybenzyl)-6-oxo-N- {(1R)-1-[4-(pentafluoro-lambda6- sulfanyl)phenyl]propyl}-1,6- dihydropyrimidine-4-carboxamide::US9815796, Example 482

SMILES CC[C@@H](NC(=O)c1cc(=O)[nH]c(Cc2ccc(OC)cc2)n1)c1ccc(cc1)S(F)(F)(F)(F)F

InChI Key InChIKey=PAPBCQQPRMYMBM-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 355391   

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355391(US9815796, Example 482 | 2-(4-methoxybenzyl)-6-oxo...)
Affinity DataKi:  3.30nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355391(US9815796, Example 482 | 2-(4-methoxybenzyl)-6-oxo...)
Affinity DataKi:  3.40nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent