BDBM355399 2-[1-(4-methoxyphenyl)-1- methylethyl]-N-[(1R)-2-methyl-1- {4- [(trifluoromethyl)sulfanyl]phenyl} propyl]-6-oxo-1,6- dihydropyrimidine-4-carboxamide::US9815796, Example 490

SMILES COc1ccc(cc1)C(C)(C)c1nc(cc(=O)[nH]1)C(=O)N[C@H](C(C)C)c1ccc(SC(F)(F)F)cc1

InChI Key InChIKey=GXCJHEVWZQTBFQ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 355399   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355399(US9815796, Example 490 | 2-[1-(4-methoxyphenyl)-1-...)
Affinity DataKi:  31nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355399(US9815796, Example 490 | 2-[1-(4-methoxyphenyl)-1-...)
Affinity DataKi:  43nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent