BDBM355615 (S)- or (R)-N-((3-fluoro-4- ((trifluoromethyl)thio)phenyl)(1- methylcyclopropyl)methyl)-6-oxo-2- phenyl-1,6-dihydropyrimidine-4- carboxamide::US9815796, Example 706::US9815796, Example 707

SMILES CC1(CC1)C(NC(=O)c1cc(=O)[nH]c(n1)-c1ccccc1)c1ccc(SC(F)(F)F)c(F)c1

InChI Key InChIKey=XNMUKOAQRKUPCY-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 355615   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355615((S)- or (R)-N-((3-fluoro-4- ((trifluoromethyl)thio...)
Affinity DataKi:  7.70nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355615((S)- or (R)-N-((3-fluoro-4- ((trifluoromethyl)thio...)
Affinity DataKi:  8.30nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355615((S)- or (R)-N-((3-fluoro-4- ((trifluoromethyl)thio...)
Affinity DataKi: >2.97E+3nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent