BDBM357035 US10214512, Example 15::methyl (9-(5-(5-chloro-2- cyanophenyl)pyridin-2-yl)-4- oxo-3-aza-1(1,3),2(1,2)- dibenzenacyclononaphane-24- yl)carbamate

SMILES COC(=O)Nc1ccc-2c(NC(=O)CCCCC(c3cccc-2c3)c2ccc(cn2)-c2cc(Cl)ccc2C#N)c1

InChI Key InChIKey=CARVFESKMXRKLT-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 357035   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357035(methyl (9-(5-(5-chloro-2- cyanophenyl)pyridin-2-yl...)
Affinity DataKi:  41nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetKallikrein-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357035(methyl (9-(5-(5-chloro-2- cyanophenyl)pyridin-2-yl...)
Affinity DataKi:  89.3nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent