BDBM357079 9-(5-(5-chloro-2-(1h-tetrazol-1- yl)phenyl)pyridin-2-yl)-25-fluoro- 3-aza-1(2,4)-pyridina-2(1,2)- benzenacyclononaphan-4-one::US10214512, Example 56

SMILES Fc1ccc2NC(=O)CCCCC(c3ccnc(c3)-c2c1)c1ccc(cn1)-c1cc(Cl)ccc1-n1cnnn1

InChI Key InChIKey=MJNFCOZBOUBSHI-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 357079   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357079(9-(5-(5-chloro-2-(1h-tetrazol-1- yl)phenyl)pyridin...)
Affinity DataKi:  14.1nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetKallikrein-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357079(9-(5-(5-chloro-2-(1h-tetrazol-1- yl)phenyl)pyridin...)
Affinity DataKi:  149nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent