BDBM357103 5-(5-chloro-2-(trifluoromethoxy)phenyl)-2-((5R,9S)-24- ((methoxycarbonyl)amino)-5-methyl-4-oxo-3-aza-1(1,3),2(1,2)- dibenzenacyclononaphane-9-yl)pyridine 1-oxide::US10214512, Example 77-a

SMILES COC(=O)Nc1ccc-2c(NC(=O)[C@H](C)CCC[C@@H](c3cccc-2c3)c2ccc(c[n+]2[O-])-c2cc(Cl)ccc2OC(F)(F)F)c1

InChI Key InChIKey=FYGORCLOXSCPCK-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 357103   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357103(5-(5-chloro-2-(trifluoromethoxy)phenyl)-2-((5R,9S)...)
Affinity DataKi:  0.850nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetKallikrein-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357103(5-(5-chloro-2-(trifluoromethoxy)phenyl)-2-((5R,9S)...)
Affinity DataKi:  1.69nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent