BDBM357140 (Z)-5-(5-chloro-2-(trifluoromethoxy)phenyl)-2-(24-((methoxycarbonyl)amino)-4-oxo-11H-3-aza-1(4,2)-imidazola-2(1,2) -benzenacyclononaphane-9-yl)pyridine 1-oxide::US10214512, Example 99-a

SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)C(CCCCC(=O)Nc2c1)c1ccc(c[n+]1[O-])-c1cc(Cl)ccc1OC(F)(F)F

InChI Key InChIKey=GFVCUIPREFSTJU-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 357140   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357140(US10214512, Example 99-a | (Z)-5-(5-chloro-2-(trif...)
Affinity DataKi:  0.170nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetKallikrein-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357140(US10214512, Example 99-a | (Z)-5-(5-chloro-2-(trif...)
Affinity DataKi:  1.21nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent