BDBM35726 sulfonamide deriv., 5a

SMILES c1cc(sc1)CC(=O)Nc2ccc(cc2)S(=O)(=O)N

InChI Key InChIKey=ZQWXOBLMDBJRLY-UHFFFAOYSA-N

Data  14 KI

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 35726   

TargetCarbonic anhydrase 7(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM35726(sulfonamide deriv., 5a)
Affinity DataKi:  6.20nMAssay Description:Inhibition of human recombinant cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 7(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM35726(sulfonamide deriv., 5a)
Affinity DataKi:  6.20nMAssay Description:Inhibition of human recombinant carbonic anhydrase 7 by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 5B, mitochondrial(Human)
Istanbul University

LigandPNGBDBM35726(sulfonamide deriv., 5a)
Affinity DataKi:  7nM ΔG°:  -11.1kcal/moleT: 2°CAssay Description:An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Human)
Istanbul University

LigandPNGBDBM35726(sulfonamide deriv., 5a)
Affinity DataKi:  7.20nM ΔG°:  -11.1kcal/moleT: 2°CAssay Description:An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM35726(sulfonamide deriv., 5a)
Affinity DataKi:  19nMAssay Description:Inhibition of human carbonic anhydrase-9 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM35726(sulfonamide deriv., 5a)
Affinity DataKi:  21nMAssay Description:Inhibition of human carbonic anhydrase-12 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istanbul University

LigandPNGBDBM35726(sulfonamide deriv., 5a)
Affinity DataKi:  50nM ΔG°:  -9.95kcal/molepH: 7.4 T: 2°CAssay Description:An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istanbul University

LigandPNGBDBM35726(sulfonamide deriv., 5a)
Affinity DataKi:  50nMAssay Description:Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istanbul University

LigandPNGBDBM35726(sulfonamide deriv., 5a)
Affinity DataKi:  50nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Istanbul University

LigandPNGBDBM35726(sulfonamide deriv., 5a)
Affinity DataKi:  61nM ΔG°:  -9.84kcal/molepH: 7.4 T: 2°CAssay Description:An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Istanbul University

LigandPNGBDBM35726(sulfonamide deriv., 5a)
Affinity DataKi:  61nMAssay Description:Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Istanbul University

LigandPNGBDBM35726(sulfonamide deriv., 5a)
Affinity DataKi:  61nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 13(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM35726(sulfonamide deriv., 5a)
Affinity DataKi:  125nMAssay Description:Inhibition of human recombinant cytosolic carbonic anhydrase 13 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 3(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM35726(sulfonamide deriv., 5a)
Affinity DataKi:  8.00E+5nMAssay Description:Inhibition of human recombinant cytosolic carbonic anhydrase 3 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed