BDBM361340 4-(6-aminopyridin-3-yl)- 1-N-(3-methylazetidin-3- yl)-3-(2H-1,2,3,4-tetrazol- 5-yl)benzene-1,2- disulfonamide hydrogen::US10221163, Example 497::US10544130, Example 497

SMILES CC1(CNC1)NS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O

InChI Key InChIKey=HGICSZSMZDNVQQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 361340   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361340(4-(6-aminopyridin-3-yl)- 1-N-(3-methylazetidin-3- ...)
Affinity DataIC50: 0.131nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361340(4-(6-aminopyridin-3-yl)- 1-N-(3-methylazetidin-3- ...)
Affinity DataIC50: 0.131nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361340(4-(6-aminopyridin-3-yl)- 1-N-(3-methylazetidin-3- ...)
Affinity DataIC50: 0.219nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361340(4-(6-aminopyridin-3-yl)- 1-N-(3-methylazetidin-3- ...)
Affinity DataIC50: 0.219nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361340(4-(6-aminopyridin-3-yl)- 1-N-(3-methylazetidin-3- ...)
Affinity DataIC50: 0.645nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361340(4-(6-aminopyridin-3-yl)- 1-N-(3-methylazetidin-3- ...)
Affinity DataIC50: 0.645nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent