BDBM361540 (S)-3-((1R,3R)- 1-(2-(2-((3- fluoropropyl) amino)ethoxy)- 3- methylpyridin- 4-yl)-3- methyl- 1,3,4,9- tetrahydro-2H- pyrido[3,4- b]indol-2-yl)- 2- methylpropanoic acid::US10221173, Example 132::US10590132, Example 132::US11046689, Example 132

SMILES C[C@@H](CN1[C@H](C)Cc2c([nH]c3ccccc23)[C@H]1c1ccnc(OCCNCCCF)c1C)C(O)=O

InChI Key InChIKey=CLEHWPAJGUZRJR-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 361540   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM361540((S)-3-((1R,3R)- 1-(2-(2-((3- fluoropropyl) amino)e...)
Affinity DataIC50: 0.980nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetEstrogen receptor [307-554](Human)
Astrazeneca

US Patent
LigandPNGBDBM361540((S)-3-((1R,3R)- 1-(2-(2-((3- fluoropropyl) amino)e...)
Affinity DataIC50: 2nMAssay Description:ERα: The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha-LBD (GST)) was assessed in competition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM361540((S)-3-((1R,3R)- 1-(2-(2-((3- fluoropropyl) amino)e...)
Affinity DataIC50: 2nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM361540((S)-3-((1R,3R)- 1-(2-(2-((3- fluoropropyl) amino)e...)
Affinity DataIC50: 2nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha-LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

LigandPNGBDBM361540((S)-3-((1R,3R)- 1-(2-(2-((3- fluoropropyl) amino)e...)
Affinity DataIC50: 4.00E+4nMAssay Description:hERG: The purpose of the hERG binding assay is to evaluate the effects of test compounds on the voltage-dependent potassium channel encoded by the hu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

LigandPNGBDBM361540((S)-3-((1R,3R)- 1-(2-(2-((3- fluoropropyl) amino)e...)
Affinity DataIC50: 4.00E+4nMAssay Description:hERG (human ether a go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

LigandPNGBDBM361540((S)-3-((1R,3R)- 1-(2-(2-((3- fluoropropyl) amino)e...)
Affinity DataIC50: 4.00E+4nMAssay Description:hERG (human ether a go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent