BDBM365316 2-(4-(4- acetylpiperazin-1- yl)phenylamino)-4- (cyclopentylamino) pyrimidine-5- carboxamide::US10533001, Example 4::US11414410, Example 4::US9868729, Example 4

SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(C(N)=O)c(NC3CCCC3)n2)cc1

InChI Key InChIKey=PWUNLPDAMZWBHF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365316   

TargetTyrosine-protein kinase SYK(Human)
Alexion Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 365316BDBM365316(2-(4-(4- acetylpiperazin-1- yl)phenylamino)-4- (cy...)
Affinity DataIC50: 550nMAssay Description:The kinase reaction is performed in a black U-bottom 96-well microtitre plate. The final reaction volume is 50 μL and contains a final concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Alexion Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 365316BDBM365316(2-(4-(4- acetylpiperazin-1- yl)phenylamino)-4- (cy...)
Affinity DataIC50: 550nMAssay Description:SYK tyrosine phosphorylation activity is measured using the LANCE Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Alexion Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 365316BDBM365316(2-(4-(4- acetylpiperazin-1- yl)phenylamino)-4- (cy...)
Affinity DataIC50: 550nMAssay Description:Syk and JAK: The activity of a specified compound as an inhibitor of a JAK kinase may be assessed in vitro or in vivo. In some embodiments, the activ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent