BDBM367315 US10226449, cpd 132::US20250017938, Compound 002-132

SMILES Cc1nnc([nH]1)-c1cc(ccc1N1CCC1)C(=O)N1CCC(CC1)c1ccc(cc1)C#N

InChI Key InChIKey=OEWKVGMSYXMOPC-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 367315   

TargetFatty acid synthase(Human)
Sagimet Biosciences

US Patent
LigandPNGBDBM367315(US10226449, cpd 132 | US20250017938, Compound 002-...)
Affinity DataIC50: 210nMAssay Description:Determination of FASN biochemical activity: The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
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TargetFatty acid synthase(Human)
Sagimet Biosciences

US Patent
LigandPNGBDBM367315(US10226449, cpd 132 | US20250017938, Compound 002-...)
Affinity DataIC50: 210nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
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TargetGenome polyprotein(HCV)
3-V Biosciences

US Patent
LigandPNGBDBM367315(US10226449, cpd 132 | US20250017938, Compound 002-...)
Affinity DataEC50:  340nMAssay Description:The antiviral activities of the compounds were assessed using the HCV1b replicon system. The replicon was constructed using the ET (luc-ubi-neo/ET) c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent