BDBM368012 2-Amino-4′-((2-aminoethyl)sulfonyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-carboxylic Acid::US10227331, Example 199

SMILES NCCS(=O)(=O)c1ccc(-c2cccc(C(O)=O)c2N)c(-c2nn[nH]n2)c1S(N)(=O)=O

InChI Key InChIKey=KZRVSOYTAVEDLE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 368012   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368012(US10227331, Example 199 | 2-Amino-4′-((2-ami...)
Affinity DataIC50: 0.197nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetVIM-1 protein(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368012(US10227331, Example 199 | 2-Amino-4′-((2-ami...)
Affinity DataIC50: 0.646nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368012(US10227331, Example 199 | 2-Amino-4′-((2-ami...)
Affinity DataIC50: 1.84nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent