BDBM368465 US10227342, Example 93

SMILES COCCNC(=O)c1c(-c2ccnc(Nc3cc(NC(=O)C=C)c(cc3OC)N(C)CCN(C)C)n2)c2ccccc2n1C

InChI Key InChIKey=ZHXZOLMZOLHODX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 368465   

TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM368465(US10227342, Example 93)
Affinity DataIC50: 750nMAssay Description:A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM368465(US10227342, Example 93)
Affinity DataIC50: 300nMAssay Description:A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM368465(US10227342, Example 93)
Affinity DataIC50: 750nMAssay Description:A compound's ability in selectively inhibiting EGFR L858R and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine pro-B cell l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM368465(US10227342, Example 93)
Affinity DataIC50: 1.00E+3nMAssay Description:A compound's ability in selectively inhibiting Her2 exon 20 YVMA insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent